Heme Induces IL-1β Secretion Through Activating NLRP3 in Kidney Inflammation

@article{Li2014HemeII,
  title={Heme Induces IL-1β Secretion Through Activating NLRP3 in Kidney Inflammation},
  author={Qianwei Li and Weihua Fu and Jiwei Yao and Zheng Ji and Yongquan Wang and Zhansong Zhou and Junan Yan and Weibing Li},
  journal={Cell Biochemistry and Biophysics},
  year={2014},
  volume={69},
  pages={495-502}
}
To produce proinflammatory master cytokine IL-1β in macrophages, two stimulation pathways are needed including TLRs-NF-κB axis and NLRPs/ASC-caspase-1 axis. Different signals including exogenous and endogenous trigger inflammatory response distinctly. Among them, the role of endogenous stimulators of inflammation is poorly understood. As a component of… CONTINUE READING