Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres.

  title={Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres.},
  author={Toru Shimizu and Alzbeta Lengalova and V{\'a}clav Mart{\'i}nek and Mark{\'e}ta Mart{\'i}nkov{\'a}},
  journal={Chemical Society reviews},
Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen storage, oxygen activation, and electron transfer when bound to the heme proteins hemoglobin, myoglobin, cytochrome P450 and cytochrome c, respectively. In addition to these prototypical heme proteins, there are emergent, critical roles of exchangeable/labile heme in signal transduction. Specifically, it has been shown that association/dissociation of heme to/from heme-responsive sensors regulates… 

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