Heme, iron, and the mitochondrial decay of ageing

  title={Heme, iron, and the mitochondrial decay of ageing},
  author={Hani Atamna},
  journal={Ageing Research Reviews},
Heme, the major functional form of iron, is synthesized in the mitochondria. Although disturbed heme metabolism causes mitochondrial decay, oxidative stress, and iron accumulation, all of which are hallmarks of ageing, heme has been little studied in nutritional deficiency, in ageing, or age-related disorders such as Alzheimer's disease (AD). Biosynthesis of heme requires Vitamin B(6), riboflavin, biotin, pantothenic acid, and lipoic acid and the minerals zinc, iron, and copper, micronutrients… CONTINUE READING


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