Hematoxylin: Mesoamerica’s Gift to Histopathology. Palo de Campeche (Logwood Tree), Pirates’ Most Desired Treasure, and Irreplaceable Tissue Stain

  title={Hematoxylin: Mesoamerica’s Gift to Histopathology. Palo de Campeche (Logwood Tree), Pirates’ Most Desired Treasure, and Irreplaceable Tissue Stain},
  author={Carlos Ortiz-Hidalgo and Sergio Pi{\~n}a‐Oviedo},
  journal={International Journal of Surgical Pathology},
  pages={14 - 4}
Hematoxylin is a basic dye derived from the heartwood of Palo de Campeche (Haematoxylum campechianum), the logwood tree native to Mexico and Central America. Haematoxylum means “bloodwood” in reference to its dark-red heartwood and campechianum refers to its site of origin, the coastal city of Campeche on the Yucatan Peninsula, Mexico. Hematoxylin is colorless but it turns into the color dye hematein after oxidation (ripening). The dyeing property of logwood was well-known to the natives of the… 
Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present.
The history of immunohistochemistry (IHC) combines physiology, immunology, biochemistry, and the work of various Nobel Prize laureates to develop this magnificent technique that is used daily in anatomical pathology laboratories worldwide.
Exotic Psyllids and Exotic Hosts: Accumulation of Nonnative Psylloidea in North America (Hemiptera)
The Psylloidea (Hemiptera) comprise ∼4,000 species of small sap-feeding insects known as psyllids or jumping plant-lice, with forty-six species considered to be nonnative accounting for ∼10% of the known North American psyllid fauna.
From Scope to Screen: The Evolution of Histology Education.
This chapter takes us on the journey through the past, present, and future of histology and its education; from technologies grounded in ancient understanding and control of the properties of light, to the ingenuity of crafting glass lenses that led to the construction of the first microscopes.
Optical density-based image analysis method for the evaluation of hematoxylin and eosin staining precision
The results show that image analysis of H & E-stained tissue sections is a viable tool for assessing and verifying staining quality and that OD analysis results for H&E-stained sections are affected by changing pre-analytical and/or reagent variables.
Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds
This review summarizes the current key advancements in natural anticancer compounds; computer-assisted/fragment-based structural elucidation and a multi-target approach for the exploration of natural compounds.
Histologic Outcomes After Guided Bone Regeneration of Peri-implant Defects Comparing Individually Shaped Block Versus Particulate Bone Substitutes.
Peri-implant bone dehiscences were grafted either with deproteinized bovine bone mineral (DBBM) block or with particulate DBBM, both covered with a collagen membrane and stabilized with resorbable pins, and rendered successful tissue integration.
Biomedical Visualisation: Volume 8
Muscle physiology constitutes a core curriculum for students and researchers within biomedical, health and exercise science disciplines. The variations between skeletal and smooth muscle, mechanisms
Differentiation of Cells Isolated from Human Femoral Heads into Functional Osteoclasts
Proper formation of the skeleton during development is crucial for the mobility of humans and the maintenance of essential organs. The production of bone is regulated by osteoblasts and osteoclasts.


Haematoxylin--from the wood.
  • R. Allison
  • Art, Medicine
    Journal of clinical pathology
  • 1999
By the end of the 19th century haematoxylin, or logwood, had been described as “without equal” as a tissue stain by Cole, although for others carmine was considered to be the “staining agent par excellence” (Bolles Lee).
The long history of hematoxylin
  • M. Titford
  • Biology, Medicine
    Biotechnic & histochemistry : official publication of the Biological Stain Commission
  • 2005
The history of hematoxylin production and use in histology is described and it is suggested that in the mid 1800s, amateur microscopists first used hemat oxylin to stain cellular components, and it remains the most popular nuclear stain in Histology.
Cochineal (Dactylopius Coccus) as One of the Most Important Insects in Industrial Dyeing
Cochineal is the name of both crimson or carmine dye and the cochineal insect (Dactylopius coccus), a scale insect from which the dye is derived, and is primarily used as a food coloring and for cosmetics.
Nuclear staining with alum hematoxylin.
The hematoxylin and eosin stain is the most common method used in anatomic pathology, yet it is a method about which technologists ask numerous questions. Hematoxylin is a natural dye obtained from a
Preface to a forthcoming series that highlights milestones in the evolution of pathology as a discipline
Documentation of disease really begins with Egyptianmedicine, where the most important sources are the EdwinSmith Papyrus (17th century BC) and Papyrus Ebers (about1550 BC), which contain information on different types of bone injuries, trachoma (Nile valley), ulceratinglumps (cancer?), parasites and other diseases.
Hematoxylin shortages: their causes and duration, and other dyes that can replace hemalum in routine hematoxylin and eosin staining
Abstract The origins of repeated hematoxylin shortages are outlined. Lack of integration in the hematoxylin trade exacerbates the problems inherent in using a natural product. Separate corporations
A brief history of pathology
There is no single event, no ‘Big Bang’, that demarcates the beginning of pathology as a defined area of interest for early medical practitioners, but over the last century, archaeological discoveries increasingly have been linked with palaeopathological investigations, furnishing a wealth of observations of gross external features of disease.
Human Colors-The Rainbow Garden of Pathology: What Gives Normal and Pathologic Tissues Their Color?
Biologic pigments have antioxidant and cytoprotective properties and should be considered as potential future therapies for disease and cancer.
The Wonderful Colors of the Hematoxylin–Eosin Stain in Diagnostic Surgical Pathology
  • J. Chan
  • Biology, Medicine
    International journal of surgical pathology
  • 2014
The spectrum, intensity, and texture of colors observed in H&E-stained slides are discussed to illustrate their value in surgical pathology diagnosis.
Wilhelm von Waldeyer‐Hartz (1836–1921): An anatomist who left his mark
Wilhelm Waldeyer was anatomist, physiologist, and pathologist during the German Empire (the so‐called Second Reich). His scientific career left many traces still noticeable today. Not only is he