Hematotoxicity and concentration-dependent conjugation of phenol in mice following inhalation exposure to benzene.

@article{Wells1991HematotoxicityAC,
  title={Hematotoxicity and concentration-dependent conjugation of phenol in mice following inhalation exposure to benzene.},
  author={Matthew S. Wells and Donald E. Nerland},
  journal={Toxicology letters},
  year={1991},
  volume={56 1-2},
  pages={159-66}
}
Benzene is metabolized to one or more hematotoxic species. Saturation of benzene metabolism could limit the production of toxic species. Saturation of phase II enzymes involved in the conjugation of the phenolic metabolites of benzene also could affect the hematotoxicity of benzene. To investigate the latter possibility, we exposed male Swiss mice, via the inhalation route, to various concentrations of benzene for 6 h per day for 5 days. Following termination of the final exposure the mice were… CONTINUE READING

Similar Papers

Loading similar papers…