Hematotoxicity and carcinogenicity of inhaled benzene.

  title={Hematotoxicity and carcinogenicity of inhaled benzene.},
  author={Eugene P. Cronkite and Robert S. Tripp Lionel Galway Paul S. Killingsworth Eric Drew and Tohru Inoue and Yoko Hirabayashi and J E Bullis},
  journal={Environmental Health Perspectives},
  pages={97 - 108}
CBA/Ca male mice have been exposed to benzene in air at 10, 25, 100, 300, 400, and 3000 ppm for variable intervals 6 hr/day, 5 days/week for up to 16 weeks. Two weeks of inhaling 10 ppm produced no hematologic effects; 25 ppm induced a significant lymphopenia. Inhalation of 100, 300, and 400 ppm produced dose-dependent decreases in blood lymphocytes, bone marrow cellularity, marrow content of spleen colony-forming units (CFU-S) and an increased fraction of CFU-S in DNA synthesis. Exposure of… CONTINUE READING


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