Hematoporphyrin derivative for detection and management of cancer

  title={Hematoporphyrin derivative for detection and management of cancer},
  author={Richard L. Lipson and Edward J. Baldes and Mary Jane Gray},
Hematoporphyrin derivative has been evaluated as a means of detecting malignancy in 121 patients suspected of having cancer. Areas examined included the cervix, vagina, tracheobronchial tree, esophagus, peritoneum and rectum. Dysplastic and neoplastic tissue was identified by red fluorescence whereas nonneoplastic tissue appeared grayish white to black. Thirty‐three of 35 primary malignancies of the cervix and vagina were detected by fluorescence. The technique was especially helpful for the… 

Hematoporphyrin-Derivative Phototherapy for Local Treatment of Cancer of the Tracheobronchial Tree

It appears that HpD phototherapy may be useful for control of only small, superficial squamous cell carcinomas of the tracheobronchial tree and only those within the range of the flexible fiberbronchoscope.

The clinical treatment of laryngeal papillomas with hematoporphyrin therapy.

It is demonstrated thatPhotodynamic activation of hematoporphyrin derivative may also be an effective therapy for papillomavirus infections of the larynx for laryngeal papilloma patients.

Hematoporphyrin derivative therapy of papillomas. Experimental study.

This work developed an animal model for experimentation and using the cottontail rabbit papillomavirus, large cutaneous papillomas were induced on the backs of Dutch Belted rabbits and intravenous administration of hematoporphyrin derivative was delivered with white light.

Hematoporphyrin derivative as a tumor marker in the detection and localization of pulmonary malignancy.

Hemmatoporphyrin and its derivatives seem to be the most effective in inducing fluorescence and therefore have been considered the most likely to prove useful in the detection and localization of lung tumors.

Hematoporphyrin as a diagnostic tool. A preliminary report of new techniques

Improvements in the quality of available Hp‐D, violet light sources, light carriers, and flexible fiberoptic bronchoscopes appear to warrant further examination of this technique for localization of early cancer.

Hematoporphyrin derivative photoradiation treatment of experimental malignant melanoma in the anterior chamber of the rabbit.

Results indicate that as a treatment HpD-PRT in itself might be insufficient but may prove to be an effective modality in combination with other tumor destructive therapies.

Role of Photodynamic Therapy in the Management of Gastrointestinal Cancer

Photodynamic therapy holds the promise of an eradication form of treatment for early cancer especially for patients deemed unfit for other treatment and may also prove a useful supplement to other techniques in order to eliminate small residual areas of tumour left after the main bulk has been removed by other methods.

Bronchoscopic localization and treatment of occult lung cancer.

The flexible fiberoptic bronchoscope is currently the standard tool for localization of radiographically occult carcinomas of the tracheobronchial tree. It allows direct inspection of proximal




The use of fluorescent endoscopy held considerable promise for becoming a valuable adjunct for the detection of malignant disease and is to be reported on.

The photodynamic properties of a particular hematoporphyrin derivative.

In 1898 Oscar Raab recognized that paramecia were sensitized to light by the aniline dye, acridine, and this finding led to extensive studies by Tappeiner and Jodlbauer and their associates, and to the introduction of the term "photodynamic action," used by TAppeiner in 1904.

Histamine and photodynamic action.

It seemed to us that the inability to alter the shock-producing mechanism by these 2 drugs, especially by pyrilamine, casts considerable doubt on the idea that histamine is the major agent in the production of shock by a photodynamic process.

Photosensitivity and heat.

During a study of photodynamic action in white mice, a review of the literature revealed that little work had been done regarding this problem, and available reports provided conflicting results.