Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice.

@article{Wang2015HematopoieticTF,
  title={Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice.},
  author={Jing Wang and Sagarika Chakrabarty and Quyen Bui and Wolfram Ruf and Fahumiya Samad},
  journal={The American journal of pathology},
  year={2015},
  volume={185 2},
  pages={524-35}
}
Failure to inhibit hepatic gluconeogenesis is a major mechanism contributing to fasting hyperglycemia in type 2 diabetes and, along with steatosis, is the hallmark of hepatic insulin resistance. Obesity is associated with chronic inflammation in multiple tissues, and hepatic inflammation is mechanistically linked to both steatosis and hepatic insulin resistance. Here, we delineate a role for coagulation signaling via tissue factor (TF) and proteinase-activated receptor 2 (PAR2) in obesity… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS