Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.

@article{Wrzesinski2007HematopoieticSC,
  title={Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.},
  author={Claudia Wrzesinski and Chrystal M. Paulos and Luca Gattinoni and Douglas C. Palmer and Andrew Kaiser and Zhiya Yu and Steven A Rosenberg and Nicholas P Restifo},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 2},
  pages={492-501}
}
Depleting host immune elements with nonmyeloablative regimens prior to the adoptive transfer of tumor-specific CD8(+) T cells significantly enhances tumor treatment. In the current study, superior antitumor efficacy was achieved by further increasing the intensity of lymphodepletion to a level that required HSC transplantation. Surprisingly, the HSC transplant and not the increased lymphodepletion caused a robust expansion of adoptively transferred tumor-specific CD8(+) T cells. The HSC-driven… CONTINUE READING

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