Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress.

@article{Xiao2012HematopoieticSC,
  title={Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress.},
  author={Nan Xiao and Kaushal Jani and Kelly Morgan and Rachel O. Okabe and Dana E. Cullen and Jonathan L. Jesneck and Glen D. Raffel},
  journal={Blood},
  year={2012},
  volume={119 21},
  pages={
          4898-907
        }
}
Aging degrades hematopoietic stem cell (HSC) functions, including stress response; however, the involved molecular pathways are incompletely defined. Murine BM conditionally deleted for One-Twenty-Two-1 (Ott1), is able to maintain lifelong hematopoiesis and has preserved numbers of long-term HSCs, yet cannot repopulate nor sustain itself after transplantation against a competitor even when Ott1 is excised after engraftment. We show, specifically under replicative stress, that Ott1-deleted HSCs… 
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