Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.

@article{Taussig2005HematopoieticSC,
  title={Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.},
  author={David Christopher Taussig and Daniel J. Pearce and Catherine D Simpson and Ama Z. S. Rohatiner and T. Andrew Lister and Gavin Kelly and Jennifer L. Luongo and Gwenn-a{\"e}l H Danet-Desnoyers and Dominique Bonnet},
  journal={Blood},
  year={2005},
  volume={106 13},
  pages={4086-92}
}
Human hematopoietic stem cells (HSCs) are generally regarded as being devoid of the markers expressed by differentiated blood cells, the lineage-specific antigens. However, recent work suggests that genes associated with the myeloid lineage are transcribed in mouse HSCs. Here, we explore whether myeloid genes are actually translated in human HSCs. We show that CD33, CD13, and CD123, well-established myeloid markers, are expressed on human long-term repopulating cells from cord blood and bone… CONTINUE READING
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