Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion

@article{Iscove1997HematopoieticSC,
  title={Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion},
  author={Norman N. Iscove and Katsuhiko Nawa},
  journal={Current Biology},
  year={1997},
  volume={7},
  pages={805-808}
}
Whether hematopoietic stem cells can proliferate without limit, or whether their regenerative capacity declines with repeated division, has been debated for decades. Prevailing opinion favours an intrinsic 'decline', a view based on the finite degree to which murine bone marrow can be serially transplanted, the diminished self-renewal of spleen colony-forming cells (CFU-s) subjected to repeated passage, and the failure of stem cells to regenerate to normal levels after even a single… CONTINUE READING

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Loss of stem cell repopulating ability upon transplantation

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