Hematopoietic stem cells and liver regeneration: differentially acting hematopoietic stem cell mobilization agents reverse induced chronic liver injury.

@article{Tsolaki2014HematopoieticSC,
  title={Hematopoietic stem cells and liver regeneration: differentially acting hematopoietic stem cell mobilization agents reverse induced chronic liver injury.},
  author={Eleftheria Tsolaki and Evangelia Athanasiou and Eleni Gounari and Nikolaos Zogas and Eleni Siotou and Minas Yiangou and Achilles Anagnostopoulos and Evangelia Yannaki},
  journal={Blood cells, molecules & diseases},
  year={2014},
  volume={53 3},
  pages={
          124-32
        }
}
Bone marrow (BM) could serve as a source of cells facilitating liver repopulation in case of hepatic damage. Currently available hematopoietic stem cell (HSC) mobilizing agents, were comparatively tested for healing potential in liver fibrosis. Carbon tetrachloride (CCl4)-injured mice previously reconstituted with Green Fluorescent Protein BM were mobilized with Granulocyte-Colony Stimulating Factor (G-CSF), Plerixafor or G-CSF+Plerixafor. Hepatic fibrosis, stellate cell activation and oval… CONTINUE READING

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