Hematopoietic stem cell transplantation for chronic granulomatous disease.

  title={Hematopoietic stem cell transplantation for chronic granulomatous disease.},
  author={Reinhard A. Seger},
  journal={Immunology and allergy clinics of North America},
  volume={30 2},
Chronic granulomatous disease (CGD) is a primary immunodeficiency disease that is caused by the lack of 1 of 5 subunits of the superoxide-producing nicotinamide adenine dinucleotide phosphate oxidase of neutrophils, macrophages, and eosinophils. Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for CGD and can be offered to selected patients. Improved outcome with supportive care and high clinical variability in the disease course, however, make… CONTINUE READING