Hematopoietic stem cell regeneration enhanced by ectopic expression of ROS-detoxifying enzymes in transplant mice.

@article{Miao2013HematopoieticSC,
  title={Hematopoietic stem cell regeneration enhanced by ectopic expression of ROS-detoxifying enzymes in transplant mice.},
  author={Weimin Miao and Richard Xufeng and M Park and Haihui Gu and Linping Hu and Jin Wook Kang and Shihui Ma and Paulina H. Liang and Yanxin Li and Haizi Cheng and Hui Yu and Michael P. Epperly and Joel Greenberger and Tao Cheng},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2013},
  volume={21 2},
  pages={423-32}
}
High levels of reactive oxygen species (ROS) can exhaust hematopoietic stem cells (HSCs). Thus, maintaining a low state of redox in HSCs by modulating ROS-detoxifying enzymes may augment the regeneration potential of HSCs. Our results show that basal expression of manganese superoxide dismutase (MnSOD) and catalase were at low levels in long-term and short-term repopulating HSCs, and administration of a MnSOD plasmid and lipofectin complex (MnSOD-PL) conferred radiation protection on irradiated… CONTINUE READING

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