Hematopoietic stem cell fate is established by the Notch-Runx pathway.

  title={Hematopoietic stem cell fate is established by the Notch-Runx pathway.},
  author={Caroline Erter Burns and David Traver and Elizabeth A. Mayhall and Jennifer L. Shepard and Leonard I. Zon},
  journal={Genes & development},
  volume={19 19},
Identifying the molecular pathways regulating hematopoietic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed the effects of Notch signaling on HSC number during zebrafish development and adulthood, defining a critical pathway for stem cell specification. The Notch signaling mutant mind bomb displays normal embryonic hematopoiesis but fails to specify adult HSCs. Surprisingly, transient Notch activation… CONTINUE READING
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