Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

Abstract

We here use knockin mutagenesis in the mouse to model the spectrum of acquired CEBPA mutations in human acute myeloid leukemia. We find that C-terminal C/EBPalpha mutations increase the proliferation of long-term hematopoietic stem cells (LT-HSCs) in a cell-intrinsic manner and override normal HSC homeostasis, leading to expansion of premalignant HSCs… (More)
DOI: 10.1016/j.ccr.2009.09.036

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@article{Bereshchenko2009HematopoieticSC, title={Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.}, author={Oxana Bereshchenko and Elena Mancini and Susan J. Moore and Daniel Bilbao and Robert M{\aa}nsson and Sidinh Luc and Amit Grover and Sten Eirik W Jacobsen and David Bryder and Claus Nerlov}, journal={Cancer cell}, year={2009}, volume={16 5}, pages={390-400} }