Hematopoietic-stem-cell-based gene therapy for HIV disease.

@article{Kiem2012HematopoieticstemcellbasedGT,
  title={Hematopoietic-stem-cell-based gene therapy for HIV disease.},
  author={Hans-Peter Kiem and Keith R. Jerome and Steven G. Deeks and Joseph M McCune},
  journal={Cell stem cell},
  year={2012},
  volume={10 2},
  pages={137-47}
}
Although combination antiretroviral therapy can dramatically reduce the circulating viral load in those infected with HIV, replication-competent virus persists. To eliminate the need for indefinite treatment, there is growing interest in creating a functional HIV-resistant immune system through the use of gene-modified hematopoietic stem cells (HSCs). Proof of concept for this approach has been provided in the instance of an HIV-infected adult transplanted with allogeneic stem cells from a… CONTINUE READING
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