Hematopoietic-stem-cell-based gene therapy for HIV disease.

  title={Hematopoietic-stem-cell-based gene therapy for HIV disease.},
  author={Hans-Peter Kiem and Keith R. Jerome and Steven G. Deeks and Joseph M McCune},
  journal={Cell stem cell},
  volume={10 2},
Although combination antiretroviral therapy can dramatically reduce the circulating viral load in those infected with HIV, replication-competent virus persists. To eliminate the need for indefinite treatment, there is growing interest in creating a functional HIV-resistant immune system through the use of gene-modified hematopoietic stem cells (HSCs). Proof of concept for this approach has been provided in the instance of an HIV-infected adult transplanted with allogeneic stem cells from a… CONTINUE READING
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HIV-1 in vivo

  • P. A. Horn, M. S. Topp, J. C. Morris, S. R. Riddell, H. P. Kiem
  • Nat. Biotechnol
  • 2002
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Engineering HIVresistant human CD 4 + T cells with CXCR 4specific zincfinger nucleases

  • C. B. Wilen, J. Wang, +7 authors A. P. Jordan
  • PLoS Pathog .
  • 2011
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Evidence for the cure of HIV infection by CCR5D32/D32 stem cell transplantation

  • T. Schneider
  • Blood 117, 2791–2799. Amado, R.G., Mitsuyasu, R.T…
  • 2011

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