Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction.


OBJECTIVE The aim of this study was to test dietary restriction (DR) as an intervention to alleviate senescence-associated functional defects in hematopoietic stem cells (HSCs). MATERIALS AND METHODS BALB/cByJ (BALB) mice were fed ad libitum (AL) or were diet restricted (DR) to 75% of the AL food intake after 1 month of age. Peripheral blood and bone… (More)