Hematopoietic rescue in mice via alpha 1-adrenoceptors on bone marrow B cell precursors.

@article{Togni1996HematopoieticRI,
  title={Hematopoietic rescue in mice via alpha 1-adrenoceptors on bone marrow B cell precursors.},
  author={M Togni and George Maestroni},
  journal={International journal of oncology},
  year={1996},
  volume={9 2},
  pages={313-8}
}
We demonstrated that adrenergic agents may affect hematopoiesis via high and low affinity al-adrenergic receptors (alpha 1-ARs) present on bone marrow cells. Here we show that the high affinity, alpha 1-AR is present on Mac1(-) B220(+)sIgM(-) (pre-B) cells. The low affinity alpha 1-AR seems to be present on Mac1(+) B220(-) cells. Noradrenaline administration in mice rescued hematopoiesis from the toxic effect of carboplatin or X-rays sublethal irradiation. The protection was reflected by higher… CONTINUE READING