Hematopoietic reconstitution after lethal irradiation and bone marrow transplantation: effects of different hematopoietic cytokines on the recovery of thymus, spleen and blood cells

@article{Frasca2000HematopoieticRA,
  title={Hematopoietic reconstitution after lethal irradiation and bone marrow transplantation: effects of different hematopoietic cytokines on the recovery of thymus, spleen and blood cells},
  author={Daniela Frasca and F. Guidi and Mariamena Arbitrio and Claudio Pioli and Fabrizio Poccia and Rosella Cicconi and G. Doria},
  journal={Bone Marrow Transplantation},
  year={2000},
  volume={25},
  pages={427-433}
}
Lethally irradiated mice were grafted with syngeneic bone marrow cells or left ungrafted. Mice of each group were injected with different hematopoietic cytokines for 5 consecutive days starting immediately after irradiation or left uninjected. The recovery of lymphoid tissues induced by hematopoietic cytokines 7 days after irradiation and bone marrow cell transplantation was comparable to that observed at days 21–28 in irradiated, bone marrow-grafted, but cytokine-uninjected mice. IL-11 or IL-6… CONTINUE READING