Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses

@article{Shui2007HematopoieticPK,
  title={Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses},
  author={Jr-Wen Shui and Jonathan S. Boomer and Jin Han and Jun Xu and Gregory A Dement and Guisheng Zhou and Tse-Hua Tan},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={84-91}
}
HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in enhanced TCR-induced phosphorylation of SLP-76, phospholipase C-γ1 and the kinase Erk, more-persistent calcium flux, and increased production of cytokines and antigen-specific antibodies. Furthermore, HPK1-deficient mice were more susceptible to experimental autoimmune encephalomyelitis. Although the interaction… CONTINUE READING

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