Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

@article{Carrizosa2009HematopoieticLC,
  title={Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.},
  author={Esteban Carrizosa and Timothy S. Gomez and Christine M. Labno and Deborah A Klos Dehring and Xiaohong Liu and Bruce D Freedman and Daniel D Billadeau and Janis K Burkhardt},
  journal={Journal of immunology},
  year={2009},
  volume={183 11},
  pages={7352-61}
}
Productive T cell activation requires efficient reorganization of the actin cytoskeleton. We showed previously that the actin-regulatory protein, hematopoietic lineage cell-specific protein 1 (HS1), is required for the stabilization of F-actin and Vav1 at the immunological synapse and for efficient calcium responses. The Tec family kinase IL-2-inducible T cell kinase (Itk) regulates similar aspects of T cell activation, suggesting that these proteins act in the same pathway. Using video… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Actin Engine in Immunological Synapse

Immune network • 2012
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 50 references

T cell antigen receptor signaling and immunological synapse stability require myosin

T. Ilani, G. Vasiliver-Shamis, S. Vardhana, A. Bretscher, M. L. Dustin
IIA. Nat. Immunol • 2009

Similar Papers

Loading similar papers…