Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1.

  title={Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1.},
  author={Robert Hromas and Attilio Orazi and Richard S Neiman and Richard A Maki and C Van Beveran and Jennifer Moore and Michael J. Klemsz},
  volume={82 10},
The ETS oncogene family member PU.1 is a transcriptional activator that is dysregulated by Friend erythroleukemia virus insertion. Northern analysis found that PU.1 is highly expressed in cells of myeloid and B-lymphoid origin, but not expressed at all in a number of nonhematopoietic tissues. Interferon-gamma and retinoic acid downregulated PU.1 expression in marrow macrophages. In situ immunohistochemistry found that PU.1 is expressed only in early granulocytic and erythroid cells and… CONTINUE READING
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