Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1.

  title={Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1.},
  author={Susana Navarro and N{\'e}stor W. Meza and Oscar Quintana-Bustamante and Jose A Casado and Ariana Jacome and Kimberly Ann McAllister and Silvia Puerto and Jordi Surrall{\'e}s and Jos{\'e} C Segovia and Juan Antonio Bueren},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={14 4},
We have investigated the hematopoietic phenotype of mice with a hypomorphic mutation in the Brca2/Fancd1 gene (Brca2(Delta27/Delta27) mutation). In contrast to observations made in other Fanconi anemia (FA) mouse models, low numbers of hematopoietic colony-forming cells (CFCs) were noted in Brca2(Delta27/Delta27) mice, either young or adult. Additionally, a high incidence of spontaneous chromosomal instability was observed in Brca2(Delta27/Delta27) bone marrow (BM) cells, but not in Brca2… CONTINUE READING