Hematopoietic cytokines as tumor markers

@article{Mroczko2001HematopoieticCA,
  title={Hematopoietic cytokines as tumor markers},
  author={Barbara Mroczko and Maciej Szmitkowski},
  journal={Clinical Chemistry and Laboratory Medicine (CCLM)},
  year={2001},
  volume={42},
  pages={1347 - 1354}
}
Abstract Stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor (G-CSF) and macrophage-colony stimulating factor (M-CSF) are members of a group of glycoproteins called hematopoietic cytokines (HCs). These cytokines regulate the growth and differentiation of hematopoietic progenitor cells and functionally activate mature neutrophils or macrophages. The effect of HCs is not limited to bone marrow cells. Some… 
View on PubMed
doi.org
21 Citations
Highly Influential Citations
1
Background Citations
6

Tables from this paper

21 Citations

An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer
TLDR
This study for the first time identifies a progression-promoting function of GM-CSF in colon cancer by inducing EMT, and reveals that MAPK/ERK signaling and EMT-inducing transcription factor ZEB1 are critical to mediate these effects.
Synergistic effect of SCF and G-CSF on stem-like properties in prostate cancer cell lines
TLDR
The results indicate a favorable bone marrow niche for prostate cancer cells where higher levels of cell stemness are maintained at least partly by the cytokines SCF and G-CSF.
Characterization of hematopoietic potential of mesenchymal stem cells
TLDR
The potential of ASCs to generate functional macrophages in vitro is characterized, and therefore paves way for their possible use in cell therapy applications.
GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expression
TLDR
A striking increase in tumor cell invasion into the surrounding tissue concomitant with the induction of an activated tumor stroma in GM‐ CSF overexpressing or GM‐CSF treated tumors is observed.
Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC
TLDR
It is suggested that nicotine might be promoting NSCLC growth and metastasis by inducing the secretion of SCF, and the possibility that targeting signalling cascades that activate E2F1 might be an effective way to combat NSCLCs is raised.
Tumor–platelet interaction in solid tumors
TLDR
Three questions about increased platelet counts are addressed within the review of the current literature to provide a comprehensive overview of the currently concepts in tumor–platelet interaction.
Tumor-associated macrophages in the prospect of development of targeted anticancer
TLDR
In this review, the main groups of the antitumor therapy methods, which include the use of TAM, which are directed towards the suppression of tumor angiogenesis, and which are also directed to reactivation of antitumors action of mononuclear phagocytes, are analyzed.
Characteristics of hematopoietic stem cells of umbilical cord blood
TLDR
The differences (in phenotype, cytokine production, quantity and quality of cells) between stem cells from umbilical cord blood, bone marrow and peripheral blood are described.
Cytokines Regulating Trophoblast Invasion
TLDR
This review touches upon a list of mediators that are vital for reproduction, and summarizes what is described in the literature on how these mediators are distributed within the reproductive tract, which cells are expressing their respective receptors and how they modify trophoblast function.
Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer.
TLDR
Differential diagnosis of CRC can be improved by new biomarker classes and their combination assessed by novel multiplex immunoassay.
...
...

References

SHOWING 1-10 OF 82 REFERENCES
Various human hematopoietic growth factors (interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of nonhematopoietic tumor cells.
TLDR
These results represent the first evidence that a variety of hematopoietic growth factors can stimulate the growth of clonogenic cells of some nonhematopoetic malignant cell lines in vitro.
Hematopoietic Growth Factors in Colorectal Cancer Patients
TLDR
Results suggest that M-CSF is, among the tested HGFs, the best candidate for a colorectal cancer tumor marker.
Stem Cell Factor and Granulocyte-Macrophage-Colony Stimulating Factor as Candidates for Tumour Markers for Non-Small-Cell Lung Cancer
TLDR
A potential role of SCF and GM-CSF as tumour markers for non-small-cell lung cancer (NSCLC) is suggested.
Stimulation of immune-suppressive bone marrow cells by colony-stimulating factors.
TLDR
During heightened periods of myelopoiesis, induction of bone marrow-derived immune suppressor cells may be stimulated by CSFs, such as by the singular or combined effects of GM-CSF and IL-3.
Granulocyte-macrophage-colony stimulating factor in patients with colorectal cancer.
TLDR
The results suggest that GM-CSF may be useful as tumour marker in colorectal cancer, but further studies are needed.
Nonhematopoietic tumor cells express functional GM-CSF receptors.
TLDR
Findings indicate that nonhematopoietic cells can bind and respond to GM-CSF, suggesting additional biological activities as well as the possibility of tumor responses when GM- CSF is used therapeutically in humans.
Expression of granulocyte and granulocyte-macrophage colony-stimulating factors by human non-hematopoietic tumor cells.
TLDR
Interestingly, granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA was concomitantly expressed in most of these G- CSF-producing tumors, and relatively high frequency of this phenomenon suggests the presence of common transcriptional factors acting on regulatory regions of G-CSFs and GM-CSf genomes.
Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor.
TLDR
Results strongly suggest that G-CSF production by the bladder cancer cells studied augments autocrine growth, and recommend exercising caution in the clinical use of G- CSF for bladder cancer patients.
Effects of hematopoietic growth factors on malignant nonhematopoietic cells.
TLDR
T tumor growth stimulation by rhGM-CSF and rhIL-3 as potential hazards for their clinical application in cancer patients in conjunction with cytotoxic chemotherapy is unlikely.
Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors.
TLDR
Binding experiments with 125I-SCF show that some human solid tumor cell lines display high-affinity c-kit receptors and produce SCF, which can be detected on the cell surface, suggesting the possibility that autocrine production of SCF by c-Kit receptor-bearing tumor cells may enhance cell growth in tumor cell Lines.
...
...