Hematopoietic cell transplantation for the induction of allo- and xenotolerance.

  title={Hematopoietic cell transplantation for the induction of allo- and xenotolerance.},
  author={Megan Sykes},
  journal={Clinical transplantation},
  volume={10 4},
Durable tolerance can be reliably achieved by inducing engraftment of allogeneic or xenogeneic hematopoietic cells in recipients initially depleted of T lymphocytes. Engraftment of pluripotent hematopoietic stem cells (PPHSC) provides a constant supply of donor antigen to ensure the ongoing central deletion of donor-reactive T cell clones, resulting in a permanent state of donor-specific tolerance. Because of the toxicity of myeloablative therapy used to achieve allogeneic PPHSC engraftment… CONTINUE READING


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