Hematopoietic and endothelial differentiation of human induced pluripotent stem cells.

  title={Hematopoietic and endothelial differentiation of human induced pluripotent stem cells.},
  author={Kyung-Dal Choi and Junying Yu and Kim Smuga-Otto and Giorgia Salvagiotto and William M. Rehrauer and Maxim A. Vodyanik and James Thomson and Igor I Slukvin},
  journal={Stem cells},
  volume={27 3},
Induced pluripotent stem cells (iPSCs) provide an unprecedented opportunity for modeling of human diseases in vitro, as well as for developing novel approaches for regenerative therapy based on immunologically compatible cells. In this study, we employed an OP9 differentiation system to characterize the hematopoietic and endothelial differentiation potential of seven human iPSC lines obtained from human fetal, neonatal, and adult fibroblasts through reprogramming with POU5F1, SOX2, NANOG, and… CONTINUE READING
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