Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs.

@article{Moore1997HematopoieticAO,
  title={Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs.},
  author={Kateri Moore and Bronislaw Pytowski and Larry Witte and Daniel J. Hicklin and Ihor Lemischka},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 8},
  pages={4011-6}
}
Primitive hematopoietic stem cells are closely associated with discrete in vivo microenvironments. These "niches" are thought to provide the molecular signals that mediate stem cell differentiation and self-renewal. We have dissected the fetal liver microenvironment into distinct cellular components by establishing an extensive panel of stromal cell lines. One particular cell line maintains repopulating stem cells for prolonged in vitro culture periods. A subtraction cloning strategy has… CONTINUE READING
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