Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions

  title={Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions},
  author={Jeffrey M. Bernitz and Huen Suk Kim and Ben D. MacArthur and Hans B. Sieburg and Kateri Moore},
The ability of cells to count and remember their divisions could underlie many alterations that occur during development, aging, and disease. We tracked the cumulative divisional history of slow-cycling hematopoietic stem cells (HSCs) throughout adult life. This revealed a fraction of rarely dividing HSCs that contained all the long-term HSC (LT-HSC) activity within the aging HSC compartment. During adult life, this population asynchronously completes four traceable symmetric self-renewal… CONTINUE READING
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Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion.

Proceedings of the National Academy of Sciences of the United States of America • 2010
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