Hematopoietic Stem Cell Transplantation in Late‐Onset Krabbe Disease: No Evidence of Worsening Demyelination and Axonal Loss 4 Years Post‐allograft

@article{Laule2018HematopoieticSC,
  title={Hematopoietic Stem Cell Transplantation in Late‐Onset Krabbe Disease: No Evidence of Worsening Demyelination and Axonal Loss 4 Years Post‐allograft},
  author={C. Laule and I. Vavasour and E. Shahinfard and B. M{\"a}dler and J. Zhang and D. Li and A. MacKay and S. Sirrs},
  journal={Journal of Neuroimaging},
  year={2018},
  volume={28}
}
  • C. Laule, I. Vavasour, +5 authors S. Sirrs
  • Published 2018
  • Medicine
  • Journal of Neuroimaging
  • Late‐onset adult Krabbe disease is a very rare demyelinating leukodystrophy, affecting less than 1 in a million people. Hematopoietic stem cell transplantation (HSCT) strategies can stop the accumulation of toxic metabolites that damage myelin‐producing cells. We used quantitative advanced imaging metrics to longitudinally assess the impact of HSCT on brain abnormalities in adult‐onset Krabbe disease. 
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