Hematopoietic Stem Cell Development Is Dependent on Blood Flow

  title={Hematopoietic Stem Cell Development Is Dependent on Blood Flow},
  author={Trista E. North and Wolfram Goessling and Marian C. E. Peeters and Pulin Li and Craig J Ceol and Allegra M. Lord and Gerhard J. Weber and James Harris and Claire C. Cutting and Paul Huang and Elaine Dzierzak and Leonard I. Zon},
During vertebrate embryogenesis, hematopoietic stem cells (HSCs) arise in the aorta-gonads-mesonephros (AGM) region. We report here that blood flow is a conserved regulator of HSC formation. In zebrafish, chemical blood flow modulators regulated HSC development, and silent heart (sih) embryos, lacking a heartbeat and blood circulation, exhibited severely reduced HSCs. Flow-modifying compounds primarily affected HSC induction after the onset of heartbeat; however, nitric oxide (NO) donors… CONTINUE READING
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