Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.

@article{Roderick2014HematopoieticRD,
  title={Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.},
  author={Justine E. Roderick and Nicole M. Hermance and Matija Zelic and Matthew J Simmons and Apostolos Polykratis and Manolis Pasparakis and Michelle A Kelliher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 40},
  pages={
          14436-41
        }
}
  • Justine E. Roderick, Nicole M. Hermance, +4 authors Michelle A Kelliher
  • Published in
    Proceedings of the National…
    2014
  • Biology, Medicine
  • Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is recruited to the TNF receptor 1 to mediate proinflammatory signaling and to regulate TNF-induced cell death. RIPK1 deficiency results in postnatal lethality, but precisely why Ripk1(-/-) mice die remains unclear. To identify the lineages and cell types that depend on RIPK1 for survival, we generated conditional Ripk1 mice. Tamoxifen administration to adult RosaCreER(T2)Ripk1(fl/fl) mice results in lethality caused by cell death… CONTINUE READING

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