Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells

@inproceedings{Wang2010HematopoieticPR,
  title={Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells},
  author={Lin Wang and Jonathan Learoyd and Yingli Duan and Alan R. Leff and Xiangdong Zhu},
  booktitle={Journal of Inflammation},
  year={2010}
}
BackgroundPyk2 is a non-receptor cytoplasmic tyrosine kinase that belongs to the focal adhesion kinase family and has been implicated in neutrophil spreading and respiratory burst activity caused by TNF-α. However, the role of Pyk2 in neutrophil migration is incompletely defined. In this study, we tested the hypothesis that Pyk2 regulates the migration of neutrophil-like differentiated HL-60 cells subsequent to β2-integrin mediated cell adhesion.MethodsHL-60 cells were induced to differentiate… CONTINUE READING

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