Hematopoietic Protein-1 Regulates the Actin Membrane Skeleton and Membrane Stability in Murine Erythrocytes

@inproceedings{Chan2013HematopoieticPR,
  title={Hematopoietic Protein-1 Regulates the Actin Membrane Skeleton and Membrane Stability in Murine Erythrocytes},
  author={Maia M. Chan and Jason M. Wooden and Mark C. M. Tsang and Diana M. Gilligan and Dinesh K. Hirenallur-S and Greg L. Finney and Eric Rynes and Michael J. MacCoss and Julita A Ram{\'i}rez and Heon Bo Park and Brian M Iritani},
  booktitle={PloS one},
  year={2013}
}
Hematopoietic protein-1 (Hem-1) is a hematopoietic cell specific member of the WAVE (Wiskott-Aldrich syndrome verprolin-homologous protein) complex, which regulates filamentous actin (F-actin) polymerization in many cell types including immune cells. However, the roles of Hem-1 and the WAVE complex in erythrocyte biology are not known. In this study, we utilized mice lacking Hem-1 expression due to a non-coding point mutation in the Hem1 gene to show that absence of Hem-1 results in microcytic… CONTINUE READING
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