Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice.

@article{Otten2013HematopoieticGR,
  title={Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice.},
  author={Jeroen J. T. Otten and Saskia C.A. de Jager and Annemieke Kavelaars and Tom Seijkens and Ilze Bot and Erwin Wijnands and Linda Beckers and Marijke M. Westra and Martine Bot and Matthias Busch and Beatriz Berm{\'u}dez and Theo J. C. van Berkel and Cobi J Heijnen and Erik A. L. Biessen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 1},
  pages={
          265-76
        }
}
Leukocyte chemotaxis is deemed instrumental in initiation and progression of atherosclerosis. It is mediated by G-protein-coupled receptors (e.g., CCR2 and CCR5), the activity of which is controlled by G-protein-coupled receptor kinases (GRKs). In this study, we analyzed the effect of hematopoietic deficiency of a potent regulator kinase of chemotaxis (GRK2) on atherogenesis. LDL receptor-deficient (LDLr(-/-)) mice with heterozygous hematopoietic GRK2 deficiency, generated by bone marrow… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Role of myeloid-specific G-protein coupled receptor kinase-2 in sepsis.

  • International journal of clinical and experimental medicine
  • 2011
VIEW 1 EXCERPT

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2010

Microglial / macrophage GRK 2 determines duration of peripheral IL - 1 - induced hyperalgesia : contribution of spinal cord CX 3 CR 1 , p 38 and IL - 1 signaling

H. L. Willemen, N. Eijkelkamp, +5 authors A. Kavelaars
  • Pain
  • 2010