Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice.

@article{Tang2016HematopoieticAD,
  title={Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice.},
  author={Chongren Tang and Yuhua Liu and Wendy Q Yang and Carl Storey and Tim S McMillen and Barbara A. Houston and Jay W. Heinecke and Ren{\'e}e C Leboeuf},
  journal={Journal of lipid research},
  year={2016},
  volume={57 1},
  pages={100-8}
}
Low-grade chronic inflammation plays an important role in the pathogenesis of obesity-induced insulin resistance. ABCA1 is essential for reverse cholesterol transport and HDL synthesis, and protects against macrophage inflammation. In the present study, the effects of ABCA1 deficiency in hematopoietic cells on diet-induced inflammation and insulin resistance were tested in vivo using bone marrow transplanted (BMT)-WT and BMT-ABCA1(-/-) mice. When challenged with a high-fat high-carbohydrate… CONTINUE READING