Hematopoiesis is not clonal in healthy elderly women.

  title={Hematopoiesis is not clonal in healthy elderly women.},
  author={Sabina I. Swierczek and Neeraj Agarwal and Roberto H Nussenzveig and Gerald Rothstein and Andrew Wilson and Andrew S. Artz and Josef T Prchal},
  volume={112 8},
Clonality assays, based on X-chromosome inactivation, discriminate active from inactive alleles. Skewing of X-chromosome allelic usage, based on preferential methylation of one of the HUMARA alleles, was reported as evidence of clonal hematopoiesis in approximately 30% of elderly women. Using a quantitative, transcriptionally based clonality assay, we reported X-chromosome-transcribed allelic ratio in blood cells of healthy women consistent with random X-inactivation of 8 embryonic… CONTINUE READING


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Monoallelic gene expression in health and disease [letter

RH Nussenzveig, JT Prchal
Hematologist • 2008

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