Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell-derived hematopoietic progenitor cells.

@article{Chan2008HematopoiesisAI,
  title={Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell-derived hematopoietic progenitor cells.},
  author={Kun-Ming Chan and Sabrina Bonde and Hannes Klump and Nicholas Zavazava},
  journal={Blood},
  year={2008},
  volume={111 6},
  pages={2953-61}
}
The ability of embryonic stem (ES) cells to form cells and tissues from all 3 germ layers can be exploited to generate cells that can be used to treat diseases. In particular, successful generation of hematopoietic cells from ES cells could provide safer and less immunogenic cells than bone marrow cells, which require severe host preconditioning when transplanted across major histocompatibility complex barriers. Here, we exploited the self-renewal properties of ectopically expressed HOXB4, a… CONTINUE READING