Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1.

@article{Vega2015HematolymphoidNA,
  title={Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1.},
  author={Francisco Vega and Leonard Jeffrey Medeiros and Carlos E Bueso-Ramos and Patricia Berm{\'u}dez and Roberto N. Miranda},
  journal={American journal of clinical pathology},
  year={2015},
  volume={144 3},
  pages={
          377-92
        }
}
OBJECTIVES This session of the 2013 Society for Hematopathology/European Association for Haematopathology Workshop was dedicated to tumors currently included in the World Health Organization (WHO) classification category of myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1. METHODS We use the cases submitted to this session to review the clinicopathologic and genetic spectrum of these neoplasms, methods for their diagnosis, and issues related to… 

Myeloid/Lymphoid Neoplasms Associated With Eosinophilia and Rearrangements of PDGFRA, PDGFRB, or FGFR1 or With PCM1-JAK2.

TLDR
Accurate diagnosis and classification of this category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2 rearrangements has important therapeutic implications.

Synchronous T lymphoblastic lymphoma and myeloid neoplasm with PDGFRA rearrangement

A rare but distinct entity ‘myeloid/lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA’ has first been described in 2008 and then in 2016 World Health Organization (WHO) classification

Myeloid and Lymphoid Neoplasms with Eosinophilia

Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 were first formally accepted as a set of entities in the 2008 edition of the World Health Organization’s

Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology.

TLDR
These new NCCN Guidelines include recommendations for the diagnosis, staging, and treatment of any one of the myeloid/lymphoid neoplasms with eosinophilia (MLN-Eo) and a TK fusion gene included in the 2017 WHO Classification, as well as MLN- Eo and a FLT3 or ABL1 rearrangement.

Clinical, hematological and cytogenetic profile in fibroblast growth factor receptor 1 rearranged hematoloymphoid malignancies

TLDR
Clinical, biochemical, molecular and cytogenetic features observed in these cases are described and the CNTRL/FGFR1 fusion as identified by conventional cytogenetics and confirmed by molecular studies are described.

The power of the partner: defying expectations in a case of a myeloproliferative neoplasm with FGFR1 rearrangement

TLDR
A case of a man with an FGFR1-rearranged MPN who continues to be remarkably well eight years after diagnosis, with no mutations in JAK2 exons 12-14, CALR, MPL, CSF3R, and RUNX1.

Fibroblast growth factor receptor-1 associated myeloproliferative neoplasm and T-lymphoblastic lymphoma

TLDR
The case of a 30-year-old-woman who was diagnosed with T-lymphoblastic lymphoma from lymph node biopsy and myeloproliferative neoplasm with eosinophilia from bone marrow studies is presented to create awareness among physicians about this rare condition associated with dual malignancies.

Systematic use of fluorescence in‐situ hybridisation and clinicopathological features in the screening of PDGFRB rearrangements of patients with myeloid/lymphoid neoplasms

TLDR
This work aims to develop a broader strategy for screening of PDGFRB rearrangements of patients with myeloid/lymphoid neoplasms with high sensitivity to tyrosine kinase inhibitors.

Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA , PDGFRB , FGFR1, or t(8;9)(p22;p24.1); PCM1-JAK2

TLDR
This chapter will further divulge additional details regarding this heterogeneous group of neoplasms including description of various fusion partners with PDGFRA, PDGFRB, and FGFR1.

Multiple MYO18A-PDGFRB fusion transcripts in a myeloproliferative neoplasm patient with t(5;17)(q32;q11)

TLDR
It is proved that MYO18A-PDGFRB fusions are recurrent genetic aberrations involved in MPNs, and multiple fusion transcripts with novel breakpoints are identified.

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