Hematological and histopathological changes in Rattus norvegicus (Wistar) experimentally infected by Angiostrongylus cantonensis (Chen, 1935).

  title={Hematological and histopathological changes in Rattus norvegicus (Wistar) experimentally infected by Angiostrongylus cantonensis (Chen, 1935).},
  author={Juberlan da Silva Garcia and Tatiane Cristina dos Santos Bonfim and Arnaldo Maldonado Junior and Victor Menezes Tunholi and Vin{\'i}cius Menezes Tunholi-Alves and Esther Maria Mota and Raquel de Oliveira Sim{\~o}es and Andr{\'e} Campos Santana and Cl{\'e}ber S Hooper and Jairo Pinheiro and M{\'a}rcio Neves B{\'o}ia},
  journal={Parasitology international},
  volume={63 4},
Eosinophilic meningitis caused by Angiostrongylus cantonensis is a zoonosis endemic to Southeast Asia and the Pacific islands. It is considered an emerging disease because it has been expanding both geographically and in terms of the range of hosts. In South America, the first cases were reported in Brazil and were attributed to eating infected snails. In this study, 70 adult females of Rattus norvegicus (Wistar) were used to evaluate hematology, blood gases, cardiac markers and lung… Expand
Achatina fulica infected by Angiostrongylus cantonensis on beaches, in the west zone of Rio de Janeiro, Brazil
The presence of Achatina fulica infected by Angiostrongylus cantonensis in restinga areas along beaches in the west zone of Rio de Janeiro city demonstrates the potential risk of infection for visitors and the expansion of this helminth in the State of Janeiro. Expand
Central nervous system manifestations of Angiostrongylus cantonensis infection.
The present paper reviews the life cycle, epidemiology, pathogenesis, clinical features, diagnosis, treatment, prevention and prognosis of A. cantonesis infection and focuses on the spectrum of central nervous system manifestations and disease pathogenesis. Expand
Gross, microscopic, radiologic, echocardiographic and haematological findings in rats experimentally infected with Angiostrongylus cantonensis
The cardiopulmonary changes in mature Wistar rats chronically infected with moderate burdens of A. cantonensis are comparable to those seen in dogs infected with Angiostrongylus vasorum, suggesting rats infected with A. Cantonensis could be a model for dogs with a A. vasorum infection. Expand


Metabolic and histopathological profile of Rattus norvegicus (Wistar) experimentally infected by Angiostrongylus cantonensis (Chen, 1935).
The activities of AST, ALT, ALKP and GGT in the serum and hepatic glycogen increased in response to infection, while the levels of globulin and total protein increased only in the eighth week of infection and there was a reduction in the Levels of serum glucose. Expand
Existence of Angiostrongylus cantonensis in rats (Rattus norvegicus) in Grenada, West Indies.
Evidence of the further global expansion of this important zoonotic parasite, Angiostrongylus cantonensis, is provided in Grenada for the first time in the Lesser Antilles. Expand
The giant African snail Achatina fulica as natural intermediate host of Angiostrongylus cantonensis in Pernambuco, northeast Brazil.
If A. fulica may act as intermediate host of A. cantonensis at the peridomiciliary areas of a patient's house from state of Pernambuco (PE), who was diagnosed with eosinophilic meningitis and a history of ingesting raw molluscs is assessed. Expand
Haematological alterations in Rattus norvegicus (Wistar) experimentally infected with Echinostoma paraensei (Trematoda: Echinostomatidae).
It is concluded that E. paraensei produces haematological alterations in R. norvegicus, causing regenerative anaemia, and this system can be a useful model to study the direct and indirect effects of gastrointestinal infections. Expand
First record of molluscs naturally infected with Angiostrongylus cantonensis (Chen, 1935) (Nematoda: Metastrongylidae) in Brazil.
This is the first record of Brazilian molluscs infected with this nematode species, and larvae obtained from A. fulica snails, from São Vicente, state of São Paulo, also showed genetic profiles of this Nematode. Expand
Differences of larval development and pathological changes in permissive and nonpermissive rodent hosts for Angiostrongylus cantonensis infection
Comparisons of larval size, recovery rate, distribution, and the severity of pathologic injuries in the CNS of both permissive host and nonpermissive host imply that the difference in innate immune response to parasite infection attribute to host specificity. Expand
Human angiostrongyliasis.
Educating the public about the dangers of eating raw or undercooked intermediate and paratenic hosts in endemic areas is essential for the prevention and control of this foodborne zoonotic disease. Expand
Clinical, laboratory and pathological findings in dogs experimentally infected with Angiostrongylus vasorum
Beagles inoculated with 50 or 500 A. vasorum third stage larvae obtained from experimentally infected Biomphalaria glabrata snails exhibited earlier and more severe respiratory signs and coagulopathies were slight; nevertheless coagulation parameters were inoculation dose dependent. Expand
Changes in worm burden, haematological and serological response in rats after single and multipleAngiostrongylus cantonensis infections
  • A. C. Au, R. Ko
  • Biology, Medicine
  • Zeitschrift für Parasitenkunde
  • 2004
A positive haemagglutinating antibody response was first observed in some rats as early as four weeks post-infection with 100 larvae when the worms began migrating from the brain to the lungs. Expand
Haematological and biochemical changes in dogs naturally infected with Angiostrongylus vasorum before and after treatment.
The results show that the diagnosis of canine angiostrongylosis should not be excluded based on unremarkable haematological and blood biochemical parameters, and support the recent finding that a low serum fructosamine concentration may be associated with infection with A. vasorum. Expand