Hematological Toxicology following Embryonic Exposure to Aflatoxin-B1
@article{Dietert1983HematologicalTF,
title={Hematological Toxicology following Embryonic Exposure to Aflatoxin-B1},
author={Rodney Dietert and Stephen E. Bloom and Mumtaz Ali Qureshi and Urarat Nanna},
journal={Proceedings of the Society for Experimental Biology and Medicine},
year={1983},
volume={173},
pages={481 - 485}
}Abstract The influence of embryonic exposure to aflatoxin-B1 (AF-B1) upon the erythroid system of the maturing chicken was examined using a variety of assays. Since the chick embryo is known to possess mixed-function oxidase activity, this animal serves as an excellent model system for studies of human fetal toxicology. AF-B1 (0.1 μg) was administered to either 6- or 12-day embryos by the air sac method. This level of AF-B1 was highly mutagenic and was found to induce an average of 10.6 sister…
21 Citations
Embryonic exposure to aflatoxin-B1: mutagenicity and influence on development and immunity.
- BiologyEnvironmental mutagenesis
- 1985
The results suggest that long-term selective immune depression can occur following embryonic exposure to aflatoxin-B1, and two parameters of cell-mediated immunity, graft vs host (GvH), and cutaneous basophil hypersensitivity (CBH) reactions were both depressed as a result of exposure to AF-B 1.
Effects of AFB1 embryonic exposure on chicken mononuclear phagocytic cell functions.
- Biology, MedicineDevelopmental and comparative immunology
- 1992
Developmental toxicity of aflatoxin B1 in the rodent embryo in vitro: contribution of exogenous biotransformation systems to toxicity.
- BiologyTeratology
- 1988
It was found that the embryolethality of AFB1, but not the dysmorphogenicity, could be greatly modulated by exogenous biotransformation, which suggests that separate chemical mediators may be responsible for the embryos' embryolethal and dysmorphogenic effects.
Selective aflatoxin B1‐induced sister chromatid exchanges and cytotoxicity in differentiating B and T lymphocytes in vivo
- BiologyEnvironmental and molecular mutagenesis
- 1993
Assessment of genotoxic and cytotoxic effects of the fungal metabolite aflatoxin B1 on the developing immune system of the chick embryo and in vivo bromodeoxyuridine labelling of DNA used to detect the induction of sister chromatid exchanges in lymphocytes indicates both selective genotoxicity and cytOToxicity of AfB1 toward B cells in the late stage embryo are indicated.
Effects of aflatoxin B1 on the growth processes of spermatogenic cell series in adult male rats
- Medicine, BiologyComparative Clinical Pathology
- 2012
It is concluded that the oral administration of aflatoxin B1 can decrease spermatogenic cells in a dose-dependent mode in adult Wistar male rats.
Developmental windows of differential lead-induced immunotoxicity in chickens.
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- 2001
The effects of direct and microsomal activated aflatoxin B1 on chicken peritoneal macrophages in vitro.
- Biology, MedicineVeterinary immunology and immunopathology
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Aflatoxin B1 effects on ovarian follicular growth and atresia in the rat
- BiologyComparative Clinical Pathology
- 2012
Aflatoxin B1 is toxic for all type of ovarian follicles, including non-growing and growing follicles and exerts an atretogenic effect on all types of Ovary, and its toxic effects (gametotoxicity) decreases significantly and the ovulatory follicular population either decreases or is completely depleted.
Direct and microsomal activated aflatoxin B1 exposure and its effects on turkey peritoneal macrophage functions in vitro.
- Biology, MedicineToxicology and applied pharmacology
- 1991
MORTALIDAD EMBRIONARIA EN POLLITOS CAUSADA POR AFLATOXINA B1 TRASMITIDA VÍA TRANSOVÁRICA. Embryo Mortality in Chicken Due to Aflatoxin B1 Transovarian Transmitted.
- Biology
- 2007
Embryo mortality was significantly affected by treatment 3 (4 mg/kg), lots A and B (P<0.0 1), and the effect of transovarian transmitted aflatoxin B1 in the poultry embryo mortality was studied.
References
SHOWING 1-10 OF 19 REFERENCES
Differential induction of sister chromatid exchanges by indirect-acting mutagen-carcinogens at early and late stages of embryonic development.
- BiologyEnvironmental mutagenesis
- 1980
The ability of early chick embryos to activate promutagens to forms capable of inducing SCE increases as development advances from three to six days of incubation (DI), resulting in a significant increase in the mutagenicity of the test chemicals.
Development of basal and induced aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity in the chicken embryo in ovo.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1983
The findings demonstrate development of a mixed-function oxidase system in very early embryogenesis and then in the liver as it differentiates, and adult levels of AHHase activity which would be sufficient to achieve metabolic activation of promutagens/carcinogens before and after hepatocyte differentiation.
The anemia caused by aflatoxin.
- Medicine, BiologyPoultry science
- 1975
The data suggest that a flatoxin causes a hemolytic anemia in chickens, that aflatoxin, by itself, is not involved in the hemorrhagic anemia syndrome of chickens, and that a Flatoxin does not cause in chickens a general inhibition of ribonucleic acid and protein synthesis as assumed from studies on rats.
Impairment of phagocytosis in chicken monocytes during aflatoxicosis.
- Medicine, BiologyPoultry science
- 1979
The circulating element of the mononuclear phagocyte series has reduced capacity to perform its role in host defense during aflatoxicosis.
Erythropoiesis and lymphopoiesis in the chick yolk-sac-embryo chimeras: contribution of yolk sac and intraembryonic stem cells.
- Biology, MedicineBlood
- 1982
The results obtained from the allogeneic chimeras indicate that the early chicken yolk sac produces only transiently erythroid stem cells, while intraembryonic stem cells are involved in the production of definitive erythrocytes as well as of lymphocytes, both of T and B cells.
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1975
There is a high correlation between carcinogenicity and mutagenicity: 90% (156/174) of carcinogens are mutagenic in the test and despite the severe limitations inherent in defining non-carcinogenicity, few "non-Carcinogens" show any degree of mutageniability.
Cytological detection of mutagen–carcinogen exposure by sister chromatid exchange
- BiologyNature
- 1975
A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens–carcinogens.…
Developmental disappearance of a fowl red blood cell antigen.
- BiologyThe Journal of experimental zoology
- 1968
Studies aimed at elucidating the mechanism of the developmental antigenic change suggested that the antigen or a component of the antigen is lost during development rather than being coated by a serum component or embedded in the red blood cell membrane.