Hematological Toxicology following Embryonic Exposure to Aflatoxin-B1

  title={Hematological Toxicology following Embryonic Exposure to Aflatoxin-B1},
  author={Rodney Dietert and Stephen E. Bloom and Mumtaz Ali Qureshi and Urarat Nanna},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={481 - 485}
  • R. DietertS. Bloom U. Nanna
  • Published 1 September 1983
  • Biology
  • Proceedings of the Society for Experimental Biology and Medicine
Abstract The influence of embryonic exposure to aflatoxin-B1 (AF-B1) upon the erythroid system of the maturing chicken was examined using a variety of assays. Since the chick embryo is known to possess mixed-function oxidase activity, this animal serves as an excellent model system for studies of human fetal toxicology. AF-B1 (0.1 μg) was administered to either 6- or 12-day embryos by the air sac method. This level of AF-B1 was highly mutagenic and was found to induce an average of 10.6 sister… 

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