Hematologic changes induced by intravenous administration of diacetoxyscirpenol in pigs, dogs, and calves.

@article{Coppock1989HematologicCI,
  title={Hematologic changes induced by intravenous administration of diacetoxyscirpenol in pigs, dogs, and calves.},
  author={Robert W Coppock and Walter E. Hoffmann and Howard B. Gelberg and Dorsey Bass and William B. Buck},
  journal={American journal of veterinary research},
  year={1989},
  volume={50 3},
  pages={
          411-5
        }
}
Diacetoxyscirpenol (DAS) was given IV to pigs (0, 0.5, and 1.0 mg/kg of body weight), cattle (0 and 0.5 mg/kg), and dogs (0 and 0.5 mg/kg). Blood was collected and hemograms were done at 0.5-hour intervals for 8 hours. The animals were euthanatized at 8 hours after treatment, and bone marrow samples were taken and examined by light microscopy. Moderate to severe necrosis of bone marrow hematopoietic elements was found in animals given DAS. The sequential increase in the type and number of… CONTINUE READING

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