Hematologic aspects of systemic lupus erythematosus. Current concepts.

  title={Hematologic aspects of systemic lupus erythematosus. Current concepts.},
  author={Daniel R. Budman and Alfred D. Steinberg},
  journal={Annals of internal medicine},
  volume={86 2},
Anemia occurs in more than one half of patients with systemic lupus erythematosus and is usually attributed to "chronic disease." Approximately 10% of patients with a positive Coombs' test manifest clinically significant hemolysis. Leukopenia affects both granulocytic and lymphocytic lines and may be caused by autoantibodies. Nevertheless, enhancement of B lymphocyte function occurs in active disease, perhaps due to a loss of regulatory T cells. Most patients have increased production and… CONTINUE READING