Hematogenous vertical transmission of herpes simplex virus type 1 in mice.

  title={Hematogenous vertical transmission of herpes simplex virus type 1 in mice.},
  author={Javier Santos Burgos and Carlos Ram{\'i}rez and Fernando Guzman-Sanchez and Juan M. Alfaro and Isabel Sastre and Fernando Valdivieso},
  journal={Journal of virology},
  volume={80 6},
Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that causes severe disease and death in newborn humans but, to date, it remains unclear how neonatal infection occurs. We show here that the vertical transmission of HSV-1 in mice is mainly hematogenous and involves the colonization of the neonate central nervous system (CNS). HSV-1 DNA was mainly detected in the blood and CNS of the offspring born to latently infected mothers; no significant differences were seen between the viral DNA… CONTINUE READING
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