Hemangiosarcoma in rodents: mode-of-action evaluation and human relevance.


Although rarely occurring in humans, hemangiosarcomas (HS) have become important in evaluating the potential human risk of several chemicals, including industrial, agricultural, and pharmaceutical agents. Spontaneous HS arise frequently in mice, less commonly in rats, and frequently in numerous breeds of dogs. This review explores knowledge gaps and… (More)
DOI: 10.1093/toxsci/kfp131