Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses.

@article{Margine2013HemagglutininSU,
  title={Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses.},
  author={Irina Margine and Florian Krammer and Rong Hai and Nicholas S Heaton and Gene S. Tan and Susan A Andrews and Jonathan A Runstadler and Patrick C. Wilson and Randy A Albrecht and Adolfo Garc{\'i}a-Sastre and P. Palese},
  journal={Journal of virology},
  year={2013},
  volume={87 19},
  pages={10435-46}
}
Current influenza virus vaccines contain H1N1 (phylogenetic group 1 hemagglutinin), H3N2 (phylogenetic group 2 hemagglutinin), and influenza B virus components. These vaccines induce good protection against closely matched strains by predominantly eliciting antibodies against the membrane distal globular head domain of their respective viral hemagglutinins. This domain, however, undergoes rapid antigenic drift, allowing the virus to escape neutralizing antibody responses. The membrane proximal… CONTINUE READING
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