Hemagglutinin residues of recent human A(H3N2) influenza viruses that contribute to the inability to agglutinate chicken erythrocytes.

@article{Medeiros2001HemagglutininRO,
  title={Hemagglutinin residues of recent human A(H3N2) influenza viruses that contribute to the inability to agglutinate chicken erythrocytes.},
  author={R. T. de Medeiros and Nicolas Escriou and Nadia Naffakh and Jean Claude Manuguerra and Sylvie van der Werf},
  journal={Virology},
  year={2001},
  volume={289 1},
  pages={
          74-85
        }
}
To identify the molecular determinants contributing to the inability of recent human influenza A(H3N2) viruses to agglutinate chicken erythrocytes, phenotypic revertants were selected upon passage in eggs or MDCK cells. The Leu194Ile or Val226Ile substitutions were detected in their hemagglutinin (HA) sequence concomitantly with the phenotypic reversion. Remarkably, as little as 3.5% of variants bearing a Val226Ile substitution was found to confer the ability to agglutinate chicken erythrocytes… CONTINUE READING

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