Hemagglutinin-neuraminidase of human parainfluenza 3: role of the neuraminidase in the viral life cycle.

@article{Huberman1995HemagglutininneuraminidaseOH,
  title={Hemagglutinin-neuraminidase of human parainfluenza 3: role of the neuraminidase in the viral life cycle.},
  author={Kety Huberman and Richard W. Peluso and A. R. Moscona},
  journal={Virology},
  year={1995},
  volume={214 1},
  pages={294-300}
}
The function of neuraminidase in the life cycle and pathogenesis of human parainfluenza virus type 3 (HPF3) was studied by analyzing a variant of HPF3 that has decreased neuraminidase enzymatic activity. The variant virus is more fusogenic than the wild-type virus during an acute infection. Cloning and sequencing of the fusion (F) and hemagglutinin-neuraminidase (HN) genes from this variant revealed a single amino acid change in the HN protein and no alterations in the F protein sequence… CONTINUE READING

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