Hemagglutinin (HA) proteins from H1 and H3 serotypes of influenza A viruses require different antigen designs for the induction of optimal protective antibody responses as studied by codon-optimized HA DNA vaccines.

@article{Wang2006HemagglutininP,
  title={Hemagglutinin (HA) proteins from H1 and H3 serotypes of influenza A viruses require different antigen designs for the induction of optimal protective antibody responses as studied by codon-optimized HA DNA vaccines.},
  author={Shixia Wang and Jessica Taaffe and Christopher T. Parker and Alicia Sol{\'o}rzano and Hong L Cao and Adolfo Garc{\'i}a-Sastre and Shan Lu},
  journal={Journal of virology},
  year={2006},
  volume={80 23},
  pages={11628-37}
}
Effective antibody responses provide crucial immunity against influenza virus infection. The hemagglutinin (HA) protein is the major target of protective antibody responses induced by viral infection and by vaccination with both inactivated and live-attenuated flu vaccines, but knowledge about the optimal designs of protective HA antigens from different flu serotypes is still limited. In this study, we have significantly improved the immunogenicity of HA-expressing DNA vaccines by using codon… CONTINUE READING
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